Ac-Asp-Glu-Val-Asp-pNA (Caspase-3 (Apopain) Substrate)

Product Sizes

5 mg

£261.00

ECH-860-20-5MG

25 mg

£718.00

ECH-860-20-25MG

About this Product

SKU:: ECH-860-20
CAS Number:: 189950-66-1
Extra Details:: CAS Number: 189950-66-1 \nMolecular Weight: 638.22 \nSalt Form: TFA \nPurity: >96% \nSequence (3-letter): Ac-Asp-Glu-Val-Asp-pNA \nSequence (1-letter): Ac-DEVD-pNA \nStorage: -20 ?C or below \nSolubility: DMSO and acetonitrile:methanol (1:1) to 1 mg/ml \n \nCaspase-3 (Apopain) Substrate is a colorimetric substrate for caspase-3 with the sequence Ac-DEVD-pNA. Caspase-3 is a protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Cleavage of Ac-DEVD-pNA is monitored by measuring absorbance at 405 nm. Ac-DEVD-pNA is poorly cleaved by caspase-2. \nKm = 18 ?M (Casp-1), 11 ?M (Casp-3), 32 ?M (Casp-4), 180 ?M (Casp-6), 12 ?M (Casp-7) \nReferences \n1. Talanian, R.V. et al. (1997) ?Substrate Specificities of Caspase Family Proteases? J. Biol. Chem. 272 (15): 9677?9682. \n2.Nagane, M. et al. (1998) ?Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases? Proc. Natl. Acad. Sci. USA 95 (10): 5724?5729., Echelon
Molecular Weight:: 638.22
Sequence:: Ac-Asp-Glu-Val-Asp-pNA \n
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C
Supplier:: Echelon Biosciences
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides

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