Ac-Tyr-Val-Ala-Asp-pNA (Caspase 1 (ICE) Substrate)
Product Sizes
5 mg
£241.00
ECH-860-15-5MG
25 mg
£631.00
ECH-860-15-25MG
About this Product
- SKU:
- ECH-860-15
- CAS Number:
- 149231-66-3
- Extra Details:
- CAS Number: 149231-66-3 \nMolecular Weight: 628.25 \nSalt Form: N/A \nPurity: >96% \nSequence (3-letter): Ac-Tyr-Val-Ala-Asp-pNA \nSequence (1-letter): Ac-YVAD-pNA \nStorage: -20 ?C or below \nSolubility: DMSO to 10 mM; soluble in aqueous base (e.g. 0.1 N NH4OH) to 1 mg/mL \n \nCaspase 1 (ICE) Substrate (Ac-Tyr-Val-Ala-Asp-pNA) is a substrate for interleukin 1b converting enzyme (ICE) which is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells \nKm = 23 ?M (Casp-1), 29,000 ?m (Casp-3), 874 ?M (Casp-4) \n \nActivity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm. \nReferences \n1. Alcam? A, Smith GL. A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection. Cell. 1992 71 (1): 153?167. \n2.Ayala JM, Yamin TT, Egger LA, Chin J, Kostura MJ, Miller DK. IL-1 beta-converting enzyme is present in monocytic cells as an inactive 45-kDa precursor. J Immunol. 1994 Sep 15;153(6):2592?2599. \n3.Kuida, K. et al (1995) ?Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme? Science 267 (5206): 2000-2003., Echelon
- Molecular Weight:
- 628.25
- Sequence:
- Ac-Tyr-Val-Ala-Asp-pNA \n
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Manufacturer's Data Sheet:https://www.echelon-inc.com/product/ac-tyr-val-ala-asp-pna-caspase-1-ice-substrate/
