Ac-Val-Ala-Asp-AFC (Caspase 1 (ICE) Substrate, fluorogenic)

Product Sizes

5 mg

£304.00

ECH-860-12-5MG

25 mg

£948.00

ECH-860-12-25MG

About this Product

SKU:: ECH-860-12
CAS Number:: 219137-85-6
Extra Details:: CAS Number: 219137-85-6 \nMolecular Weight: 556.18 \nSalt Form: N/A \nPurity: >96% \nSequence (3-letter): Ac-Val-Ala-Asp-AFC \nSequence (1-letter): Ac-VAD-AFC \nStorage: -20 ?C or below \n \nAc-Val-Ala-Asp-AFC is a fluorogenic substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells. \n \nActivity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm., Echelon
Molecular Weight:: 556.18
Sequence:: Ac-Val-Ala-Asp-AFC \n
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C
Supplier:: Echelon Biosciences
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides

Basket