Ac-Val-Ala-Asp-pNA (Caspase 1 (ICE) Substrate, colorimetric)

Product Sizes

5 mg

£304.00

ECH-860-11-5MG

25 mg

£598.00

ECH-860-11-25MG

About this Product

SKU:: ECH-860-11
CAS Number:: 149231-66-3
Extra Details:: CAS Number: 149231-66-3 \nMolecular Weight: 465.18 \nSalt Form: TFA \nPurity: >96% \nSequence (3-letter): Ac-Val-Ala-Asp-pNA \nSequence (1-letter): Ac-VAD-pNA \nStorage: -20 ?C or below \n \nAc-Val-Ala-Asp-pNA is a colorimetric substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells. \n \nActivity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm., Echelon
Molecular Weight:: 465.18
Sequence:: Ac-Val-Ala-Asp-pNA \n
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C
Supplier:: Echelon Biosciences
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides

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