Beta Amyloid (1-42), human
Product Sizes
0.5 mg
£330.00
ECH-641-15-0.5MG
1 mg
£583.00
ECH-641-15-1MG
5 mg
£2283.00
ECH-641-15-5MG
25 mg
£10534.00
ECH-641-15-25MG
About this Product
- SKU:
- ECH-641-15
- CAS Number:
- 107761-42-2
- Extra Details:
- CAS Number: 107761-42-2 \nMolecular Weight: 4511.3 \nSalt Form: TFA \nPurity: >95% \nSequence (3-letter): Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH \nSequence (1-letter): DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH \nStorage: -20 ?C or below \nSolubility: 1 mg/mL in 50 mM Tris or dissolve 1 mg in 70-80 uL 1% NH4OH then dilute to 1 mg/mL with 1X PBS. Do not store in 1% NH4OH, dilute immediately with PBS. \n \nBeta amyloid (1-42) is the predominant form of ?-amyloid protein found in the brains of patients with Alzheimer?s disease and Down?s syndrome. Beta amyloid down-regulates bcl-2 (a key anti-apoptotic protein) and upregulates bax (cell death promoter) with evidence suggesting that it renders neurons vulnerable to age-dependent stress and neurodegeneration \nReferences \n1. Scheuner, D. et al (1996) ?Secreted amyloid bold beta?protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease? Nat. Med. 2: 864 ? 870. \n2. Lacor, P. N. et al (2004) ?Synaptic Targeting by Alzheimer's-Related Amyloid ? Oligomers? J. Neurosci. 24 (45): 10191-10200. \n3.Paradis et al (1996) ?Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons? J. Neurosci. 16: 7533., Echelon
- Molecular Weight:
- 4511.3
- Sequence:
- Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH \n
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Manufacturer's Data Sheet:https://www.echelon-inc.com/product/beta-amyloid-1-42-human/
