Apamin, bee venom (SS1-11, SS3-15)
Product Sizes
0.5 mg
£256.00
ECH-425-10-0.5MG
1 mg
£410.00
ECH-425-10-1MG
About this Product
- SKU:
- ECH-425-10
- CAS Number:
- 24345-16-2
- Extra Details:
- CAS Number: 24345-16-2 \nMolecular Weight: 2029.93 \nSalt Form: Acetate \nPurity: >96% \nSequence (3-letter): Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11, Cys3-Cys15) \nSequence (1-letter): CNCKAPETALCARRCQQH-NH2 \nStorage: -20 ?C or below \nSolubility: water to 1 mg/mL \n \nApamin is a peptide toxin found in bee venom that is known to cross the blood-brain barrier. Apamin potently blocks ATP-type Ca+2-activated K+ channels SK1, SK2 and SK3 (low nM to sub-nM IC50), but is inactive against SK4. Apamin is used to elucidate the roles of SK channels in neurons and some cancer cells. It is a globular peptide with disulfide bridges between Cys1-Cys11 (SS1-11) and Cys3-Cys15 (SS3-15). \nReferences \n1. Blatz, A.L. and Magleby, K.L. (1986) ?Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle? Nature 323: 718 ? 720. \n2.Burnham, M.P. et al. (2002) ?Characterization of an apamin-sensitive small-conductance Ca2+-activated K+ channel in porcine coronary artery endothelium: relevance to EDHF? Br. J. Pharmacol. 135 (5): 1133?1143., Echelon
- Molecular Weight:
- 2029.93
- Sequence:
- Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11, Cys3-Cys15) \n
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Manufacturer's Data Sheet:https://www.echelon-inc.com/product/apamin-bee-venom-ss1-11ss3-15/
