Endothelin 1, human
Product Sizes
0.5 mg
£444.00
ECH-331-25-0.5MG
1 mg
£739.00
ECH-331-25-1MG
About this Product
- SKU:
- ECH-331-25
- CAS Number:
- 117399-94-7
- Extra Details:
- CAS Number: 117399-94-7 \nMolecular Weight: 2494.06 \nSalt Form: TFA \nPurity: >96% \nSequence (3-letter): Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH \nSequence (1-letter): CSCSSLMDKECVYFCHLDIIW-OH \nStorage: -20 ?C or below \nSolubility: >1 mg/ml in water \n \nEndothelin-1 is one of three isoforms of human endothelin (ET-1). It is a potent vasoconstrictor that is expressed by many cell types, with the vascular endothelium being most prominent. ET-1 is also produced by many tissues, including kidney, brain and lung among others. Antagonists of ET-1 receptors are used to treat pulmonary hypertension by inhibiting pulmonary vascular constriction thereby decreasing pulmonary vascular resistance. \nReferences \n1. Sanchez, O. et al. (2006) "Immunosuppressive therapy in connective tissue diseases-associated pulmonary arterial hypertension" Chest 130 (1): 182-189 \n2. Mubarak, K.K. (2010) "A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension" Respir. Med. 104 (1): 9-21 \n3.Fellner, S.K. and Arendshorst, W.J. (2004) "Endothelin A and B receptors of preglomerular vascular smooth muscle cells" Kidney International, 65: 1810?1817., Echelon
- Molecular Weight:
- 2494.06
- Sequence:
- Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH \n
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Manufacturer's Data Sheet:https://www.echelon-inc.com/product/endothelin-1-human/
