Recombinant Human IL-18
Product Sizes
50ug
£350.00
Y02821H-50UG
1mg
£2177.00
Y02821H-1MG
About this Product
- SKU:
- Y02821H
- Application:
- Bioactivity
- Extra Details:
- IL-18 (Interleukin-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. It signals through a heterodimeric receptor composed of IL-18Rα (binding chain) and IL-18Rβ (signaling chain), leading to activation of NF-κB and MAPK pathways. IL-18 exerts immunomodulatory functions by promoting Th1 immune responses and, in synergy with IL-12, induces IFN-γ production in T cells and NK cells, thereby enhancing cell-mediated immunity (e.g., in anti-tumor or anti-infection responses). Additionally, it activates NK cells, boosting their cytotoxicity and cytokine secretion. Under specific conditions—such as in combination with IL-23—IL-18 can also promote Th17 differentiation and has been implicated in models of autoimmune diseases.
- Format:
- Lyophilized powder
- Formulation:
- Lyophilized from a 0.22 um filtered solution containing 10mM PB, 5% Trehalose and 0.01% Tween 80, pH7.4
- Host:
- E. coli
- Molecular Weight:
- 18.2 kDa
- Purity:
- ≥95% by SDS-PAGE
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
