GMP Recombinant Human IL-12
Product Sizes
50ug
£798.00
G008-50UG
200ug
£5398.00
G008-200UG
About this Product
- SKU:
- G008
- Application:
- Bioactivity
- Extra Details:
- IL-12 (Interleukin-12) is a key pro-inflammatory cytokine and a member of the IL-12 family, primarily produced by antigen-presenting cells such as dendritic cells, macrophages, and B cells. It is a heterodimeric protein (p70) composed of two subunits, p35 and p40, linked by a disulfide bond. IL-12 promotes Th1 cell differentiation by activating the STAT4 signaling pathway, driving the commitment of na?ve CD4+ T cells into Th1 cells and stimulating the secretion of pro-inflammatory cytokines such as IFN-γ. It also enhances the activity of NK and T cells by promoting the proliferation and cytotoxic function of NK cells and CTLs (cytotoxic T lymphocytes). Furthermore, IL-12 suppresses Th2 responses by inhibiting IL-4-mediated Th2 cell differentiation, thereby reinforcing cell-mediated immunity.
- Format:
- Lyophilized powder
- Formulation:
- Lyophilized from a 0.22 um filtered solution containing PBS, 5% mannitol and 0.01% Tween 80, pH 7.4
- Host:
- Hamster
- Molecular Weight:
- 59.0 kDa
- Purity:
- ≥95% by SDS-PAGE
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
