CHO-CTLA4 Cells - Hamster cell lines
Product Sizes
1 each
£6257.00
305414-1EACH
About this Product
- SKU:
- 305414
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Extra Details:
- Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing. The CHO-CTLA4 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CTLA4 receptor at a medium-low level, approximately 3,000 molecules per cell. This cell line was created using an innovative landing pad technology that facilitates the targeted integration of the CTLA4 gene at a specific, pre-validated genomic locus. CTLA4, also known as CD152, is a critical immune checkpoint protein found primarily on T-cells. It functions by competing with CD28 for binding to B7 molecules (CD80 and CD86) on antigen-presenting cells, leading to the downregulation of T cell activation. This mechanism is vital for maintaining immune self-tolerance and preventing autoimmunity. CTLA4's role in modulating immune responses has made it a significant target in cancer immunotherapy, particularly in immune checkpoint blockade strategies. The expression of CXCR7 in this cell line was confirmed using flow cytometry.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Liquid N2, -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cytion
- Type:
- Cells: Cell Lines
- Manufacturer's Data Sheet:01917e6a28f974258c0576ac34bf036a
