RH-35 Cells - Rat cell lines
Product Sizes
1 each
£607.00
305210-1EACH
About this Product
- SKU:
- 305210
- Additional Names:
- H4II, H-35tc2, Reuber-H-35 hepatoma tissue culture 2, Reuber H-35 tc2, Reuber H35 tc2, H-35 Reuber tc2, H35 Reuber tc2, RH-35 tc2, RH35 tc2, H-35 tc2, H35 tc2
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Extra Details:
- The H4-II-E (also referred to as RH-35) cell line is a derivative of the Reuber H-35 rat hepatoma. This cell line originated from a liver tumor induced in a male ACI rat by exposure to the chemical carcinogen N-2-fluorenyldiacetamide. When transplanted into ACI rats, H4-II-E cells form rapidly growing tumors with histological features characteristic of poorly differentiated hepatomas. They are particularly sensitive to the induction of aryl hydrocarbon hydroxylase (AHH) activity, making them a robust system for studying enzymatic responses to polycyclic aromatic hydrocarbons and dioxin-like compounds. H4-II-E cells also serve as a model for studying cellular responses to carcinogens and radiation, given their clonogenicity and the ability to assay long-term cell survival post-treatment. Their application extends to exploring the mechanisms of enzyme induction, xenobiotic metabolism, and liver-specific toxicology. These attributes make H4-II-E an invaluable tool in cancer research and toxicological screening.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Liquid N2, -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cytion
- Type:
- Cells: Cell Lines
- Manufacturer's Data Sheet:ae527d15256847f491fca1890eef70a8
