KHM-5M Cells - Head-Neck cancer cell lines
Product Sizes
1 each
£879.00
305148-1EACH
About this Product
- SKU:
- 305148
- Additional Names:
- KHM/5M, KHM5M
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Extra Details:
- The KHM-5M cell line is an important model derived from a patient with undifferentiated thyroid carcinoma complicated by neutrophilia and malignant pleurisy. This cell line is characterized by its significant production of neutrophil chemotactic factors, specifically human interleukin 8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF). These factors are crucial in the recruitment and activation of neutrophils, which play a pivotal role in the immune response and inflammation. The KHM-5M cells were shown to possess extreme chemotactic activity, a trait that was substantiated through in vitro experiments using conditioned media from the cells and the modified Boyden chamber technique. Additionally, KHM-5M cells were transplanted into nude rats, where the infiltration of neutrophils was observed in and around the transplanted tumor tissue. This finding underscores the relevance of KHM-5M as a model for studying the interactions between tumor cells and the immune microenvironment, particularly in relation to neutrophil recruitment and function. The cell line also serves as a valuable tool for investigating the molecular mechanisms underlying cytokine production in cancer and the subsequent modification of pathological features. Through DNA cloning techniques, the chemotactic activities attributed to IL-8 and GM-CSF were confirmed, solidifying the KHM-5M cell line as a significant resource for research into cytokine-driven tumor-immune interactions.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Liquid N2, -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cytion
- Type:
- Cells: Cell Lines
- Manufacturer's Data Sheet:d1bf488fdbdc4976bd36311956aba035
