SKW-3 Cells - Leukemia cell lines
Product Sizes
1 each
£607.00
300343-1EACH
About this Product
- SKU:
- 300343
- Additional Names:
- SKW3
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Extra Details:
- The SKW-3 cell line, originally believed to be derived from the peripheral blood of a 61-year-old male diagnosed with chronic lymphocytic leukemia (CLL), represents a significant point of interest in cancer research, particularly in the study of B-cell leukemias. Over time, critical reassessments using Short Tandem Repeat (STR) profiling have illuminated an important issue-SKW-3 cells are not a pure line from the CLL patient, but are instead contaminated, now identified as a derivative of the KE-37 cell line. This revelation has profound implications for past research and future studies, emphasizing the need for rigorous cell line authentication to ensure experimental accuracy. KE-37, the true origin of the SKW-3 cells, is a B-cell line established from a patient with acute lymphoblastic leukemia (ALL). This shift in origin from CLL to ALL, due to the contamination, drastically alters the biological context and utility of the SKW-3 line. For researchers, this means that any findings or data previously attributed to CLL-specific mechanisms when using SKW-3 must be critically evaluated and potentially revised. The reclassification to a derivative of KE-37 necessitates a shift in the application of SKW-3 cells towards studies more relevant to ALL and its underlying mechanisms, rather than CLL.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Liquid N2, -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cytion
- Type:
- Cells: Cell Lines
- Manufacturer's Data Sheet:c14b5cbc6d204852a24998d260a28520
