MML-1 Cells - Skin cancer cell lines
Product Sizes
1 each
£1065.00
300288-1EACH
About this Product
- SKU:
- 300288
- Additional Names:
- MML1
- CE/IVD:
- Our cells are provided for in vitro laboratory research purposes exclusively and are not intended fo
- Extra Details:
- The MML-1 cell line is a melanoma cell line derived from malignant melanoma. This cell line is used primarily to study melanoma biology, particularly the role of extracellular vesicles (EVs) in cell-to-cell communication and tumor progression. MML-1 cells release various subtypes of EVs, including exosomes, microvesicles, and apoptotic bodies, each carrying distinct RNA cargos, such as microRNAs (miRNAs) and other non-coding RNAs. Studies using MML-1 cells have demonstrated that exosomes released from these cells contain specific miRNAs like miR-214-3p, miR-199a-3p, and miR-155-5p, which are closely associated with melanoma progression and metastasis. These miRNAs are enriched in exosomes compared to other EV types and have been linked to important melanoma-related pathways, such as the regulation of the MAPK signaling pathway and tumor microenvironment interactions. Interestingly, comparisons of miRNA profiles from MML-1-derived exosomes with clinical samples of melanoma show a significant overlap, indicating the clinical relevance of this cell model in understanding melanoma progression. In addition to miRNAs, MML-1 cells also release other non-coding RNAs such as small nucleolar RNAs (snoRNAs) and mitochondrial-associated transfer RNAs (mt-RNAs), which are differentially distributed among the EV subtypes. These findings highlight the MML-1 cell line's utility in studying the molecular mechanisms of melanoma, particularly how tumor cells communicate via EVs and influence their microenvironment.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Liquid N2, -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cytion
- Type:
- Cells: Cell Lines
- Manufacturer's Data Sheet:11b273ed7ba0461aac7715946463113b
