NR3C1 Recombinant Monoclonal Antibody
Product Sizes
50 ul
£235.00
CSB-RA958910A0HU-50UL
100 ul
£392.00
CSB-RA958910A0HU-100UL
About this Product
- SKU:
- CSB-RA958910A0HU
- Additional Names:
- Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1), NR3C1, GRL
- Application:
- ELISA, Flow Cytometry, Western Blot
- Buffer:
- phosphate buffered saline, 150mm nacl
- translate.label.attr.clone:
- 2D8
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
- Immunogen:
- A synthesized peptide derived from human GR
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:NR3C1-Antibody-12928773.html
