APC Recombinant Monoclonal Antibody
Product Sizes
50 ul
£235.00
CSB-RA951649A0HU-50UL
100 ul
£392.00
CSB-RA951649A0HU-100UL
About this Product
- SKU:
- CSB-RA951649A0HU
- Additional Names:
- Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5), APC, DP2.5
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline, 150mm nacl
- translate.label.attr.clone:
- 5F2
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
- Immunogen:
- A synthesized peptide derived from human APC
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:APC-Antibody-12928719.html
