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Antibodies

Phospho-MLKL (S358) Recombinant Monoclonal Antibody

Product Sizes
50 ul
£235.00
CSB-RA850851A358PHHU-50UL
100 ul
£392.00
CSB-RA850851A358PHHU-100UL
About this Product
SKU:
CSB-RA850851A358PHHU
Additional Names:
Mixed lineage kinase domain-like protein, hMLKL, MLKL
Application:
ELISA, Immunohistochemistry
Buffer:
phosphate buffered saline
translate.label.attr.clone:
4A6
Clonality:
Recombinant Monoclonal
Extra Details:
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Immunogen:
A synthesized peptide derived from human Phospho-MLKL (S358)
Isotype:
IgG
Physical State:
Liquid
Purification:
Affinity Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:
Cusabio
Type:
Antibody: Recombinant Antibodies
IHC image of CSB-RA850851A358phHU diluted at 1:100 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.