TERT Recombinant Monoclonal Antibody
Product Sizes
50 ul
£235.00
CSB-RA798840A0HU-50UL
100 ul
£392.00
CSB-RA798840A0HU-100UL
About this Product
- SKU:
- CSB-RA798840A0HU
- Additional Names:
- Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2), TERT, EST2 TCS1 TRT
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- phosphate buffered saline, 150mm nacl
- translate.label.attr.clone:
- 5C11
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
- Immunogen:
- A synthesized peptide derived from human TERT
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:TERT-Antibody-12928716.html
