Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Product Sizes
50 ul
£235.00
CSB-RA026244A127PHHU-50UL
100 ul
£392.00
CSB-RA026244A127PHHU-100UL
About this Product
- SKU:
- CSB-RA026244A127PHHU
- Additional Names:
- Transcriptional coactivator YAP1, Protein yorkie homolog, Yes-associated protein YAP65 homolog, YAP1, YAP65
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline
- translate.label.attr.clone:
- 3F3
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).
- Immunogen:
- A synthesized peptide derived from human Phospho-YAP1 (S127)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Phospho-YAP1--S127--Antibody-12921422.html
