Phospho-IRF3 (S386) Recombinant Monoclonal Antibody
Product Sizes
50 ul
£235.00
CSB-RA011818A386PHHU-50UL
100 ul
£392.00
CSB-RA011818A386PHHU-100UL
About this Product
- SKU:
- CSB-RA011818A386PHHU
- Additional Names:
- Interferon regulatory factor 3, IRF-3, IRF3
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline
- translate.label.attr.clone:
- 4H10
- Clonality:
- Recombinant Monoclonal
- Extra Details:
- Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
- Immunogen:
- A synthesized peptide derived from human Phospho-IRF3 (S386)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:Phospho-IRF3--S386--Antibody-12921402.html
