MAPK8IP1 Antibody
Product Sizes
50 ul
£186.00
CSB-PA990282-50UL
100 ul
£334.00
CSB-PA990282-100UL
About this Product
- SKU:
- CSB-PA990282
- Additional Names:
- MAPK8IP1 antibody; IB1 antibody; JIP1 antibody; PRKM8IP antibody; C-Jun-amino-terminal kinase-interacting protein 1 antibody; JIP-1 antibody; JNK-interacting protein 1 antibody; Islet-brain 1 antibody; IB-1 antibody; JNK MAP kinase scaffold protein 1 antibody; Mitogen-activated protein kinase 8-interacting protein 1 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of Human MAPK8IP1
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:MAPK8IP1-Antibody-11104930.html
