CCDC88A Antibody
Product Sizes
100 ul
£332.00
CSB-PA988246-100UL
About this Product
- SKU:
- CSB-PA988246
- Additional Names:
- AKT iphosphorylation enhancer antibody; Akt phosphorylation enhancer antibody; APE antibody; Ccdc88a antibody; Coiled coil domain containing 88A antibody; Coiled coil domain containing protein 88A antibody; Coiled-coil domain-containing protein 88A antibody; FLJ10392 antibody; G alpha interacting vesicle associated protein antibody; G alpha-interacting vesicle-associated protein antibody; Galpha interacting vesicle associated protein antibody; Girders of actin filament antibody; Girdin antibody; GIV antibody; GRDN antibody; GRDN_HUMAN antibody; HkRP1 antibody; Hook related protein 1 antibody; Hook-related protein 1 antibody; KIAA1212 antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation By similarity. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. Enomoto A., Dev. Cell 9:389-402(2005). Simpson F., Traffic 6:442-458(2005). Hillier L.W., Nature 434:724-731(2005).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from Internal of Human Girdin.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:CCDC88A-Antibody-11084458.html
