MAPK10 Antibody
Product Sizes
100 ul
£332.00
CSB-PA932566-100UL
About this Product
- SKU:
- CSB-PA932566
- Additional Names:
- c Jun kinase 3 antibody; c-Jun N-terminal kinase 3 antibody; cJun N terminal kinase 3 antibody; FLJ12099 antibody; FLJ33785 antibody; JNK3 alpha protein kinase antibody; JNK3 antibody; JNK3A antibody; MAP kinase 10 antibody; MAP kinase antibody; MAP kinase p49 3F12 antibody; MAPK 10 antibody; Mapk10 antibody; MGC50974 antibody; mitogen activated protein kinase 10 antibody; Mitogen-activated protein kinase 10 antibody; MK10_HUMAN antibody; p493F12 antibody; p54bSAPK antibody; PRKM10 antibody; protein kinase mitogen activated 10 antibody; SAPK1b antibody; Stress activated protein kinase 1b antibody; stress activated protein kinase beta antibody; Stress activated protein kinase JNK3 antibody; Stress-activated protein kinase JNK3 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Mohit A.A., Neuron 14:67-78(1995). Lisnock J., Biochemistry 39:3141-3148(2000). Jagadish N., Biochem. J. 389:73-82(2005).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human MAPK10.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:MAPK10-Antibody-11085001.html
