FEN1 Antibody
Product Sizes
100 ul
£332.00
CSB-PA926648-100UL
About this Product
- SKU:
- CSB-PA926648
- Additional Names:
- DNase IV antibody; FEN-1 antibody; FEN1 antibody; FEN1_HUMAN antibody; Flap endonuclease 1 antibody; Flap structure specific endonuclease 1 antibody; Flap structure-specific endonuclease 1 antibody; hFEN-1 antibody; hFEN1 antibody; Maturation factor 1 antibody; MF1 antibody; Rad2 antibody
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. Murray J.M., Mol. Cell. Biol. 14:4878-4888(1994). Hiraoka L.R., Genomics 25:220-225(1995). Taylor T.D., Nature 440:497-500(2006).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human FEN1.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:FEN1-Antibody-11084947.html
