NDFIP1 Antibody
Product Sizes
100 ul
£332.00
CSB-PA921011-100UL
About this Product
- SKU:
- CSB-PA921011
- Additional Names:
- 0610010M22Rik antibody; Breast cancer associated protein SGA 1M antibody; Breast cancer-associated protein SGA-1M antibody; MGC10924 antibody; N4WBP5 antibody; Ndfip1 antibody; Nedd4 family interacting protein 1 antibody; NEDD4 family-interacting protein 1 antibody; NEDD4 WW domain binding protein 5 antibody; NEDD4 WW domain-binding protein 5 antibody; NFIP1_HUMAN antibody; Putative MAPK activating protein PM13 antibody; Putative MAPK-activating protein PM13 antibody; Putative NF kappa B activating protein 164 antibody; Putative NF-kappa-B-activating protein 164 antibody; Putative NFKB and MAPK activating protein antibody; Putative NFKB and MAPK-activating protein antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation By similarity. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. Petroziello J.M., Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. Matsuda A., Oncogene 22:3307-3318(2003). Otsuki T., DNA Res. 12:117-126(2005).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from C-terminal of Human NDFIP1.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:NDFIP1-Antibody-11086414.html
