CACNA1A Antibody
Product Sizes
50 ul
£186.00
CSB-PA907240-50UL
100 ul
£334.00
CSB-PA907240-100UL
About this Product
- SKU:
- CSB-PA907240
- Additional Names:
- CACNA1A antibody; CACH4 antibody; CACN3 antibody; CACNL1A4 antibody; Voltage-dependent P/Q-type calcium channel subunit alpha-1A antibody; Brain calcium channel I antibody; BI antibody; Calcium channel antibody; L type antibody; alpha-1 polypeptide isoform 4 antibody; Voltage-gated calcium channel subunit alpha Cav2.1 antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of Human CACNA1A
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:Rabbit-anti-human-CACNA1A-polyclonal-antibody-11104437.html
