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Antibodies

FBXW11 Antibody

Product Sizes
50 ul
£186.00
CSB-PA891721ESR2HU-50UL
100 ul
£334.00
CSB-PA891721ESR2HU-100UL
About this Product
SKU:
CSB-PA891721ESR2HU
Additional Names:
beta Transducin Repeat Containing Protein 2 antibody; BTRC2 antibody; BTRCP2 antibody; F-box and WD repeats protein beta-TrCP2 antibody; F-box and WD-40 Domain Protein 1B antibody; F-box Protein FBW1B antibody; F-box/WD repeat-containing protein 11 antibody; F-box/WD repeat-containing protein 1B antibody; FBW1B antibody; FBW1B_HUMAN antibody; FBXW11 antibody; FBXW1B antibody; Homologous to Slimb protein antibody; HOS antibody
Application:
ELISA, Immunohistochemistry
Buffer:
PBS
Clonality:
Polyclonal
Extra Details:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
Host:
Rabbit
Immunogen:
Recombinant Human F-box/WD repeat-containing protein 11 protein (1-140AA)
Isotype:
IgG
Physical State:
Liquid
Purification:
Affinity Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:
Cusabio
Type:
Antibody: Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA891721ESR2HU at dilution of 1:100
IHC image of CSB-PA891721ESR2HU diluted at 1:109 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.