BAZ2A Antibody, FITC conjugated
Product Sizes
50 ug
£186.00
CSB-PA883428HC01HU-50UG
100 ug
£334.00
CSB-PA883428HC01HU-100UG
About this Product
- SKU:
- CSB-PA883428HC01HU
- Additional Names:
- BAZ2A antibody; KIAA0314 antibody; TIP5Bromodomain adjacent to zinc finger domain protein 2A antibody; Transcription termination factor I-interacting protein 5 antibody; TTF-I-interacting protein 5 antibody; Tip5 antibody; hWALp3 antibody
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- FITC
- Extra Details:
- Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Bromodomain adjacent to zinc finger domain protein 2A protein (97-266AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:BAZ2A-AntibodyFITC-conjugated-12259655.html
