FZD8 Antibody
Product Sizes
50 ug
£186.00
CSB-PA880970LA01HU-50UG
100 ug
£334.00
CSB-PA880970LA01HU-100UG
About this Product
- SKU:
- CSB-PA880970LA01HU
- Additional Names:
- Frizzled 8 seven transmembrane spanning receptor antibody; frizzled 8, seven transmembrane spanning receptor antibody; Frizzled family receptor 8 antibody; frizzled homolog 8 (Drosophila) antibody; Frizzled homolog 8 antibody; Frizzled-8 antibody; FZ 8 antibody; Fz-8 antibody; FZ8 antibody; FZD 8 antibody; FZD8 antibody; FZD8_HUMAN antibody; hFZ 8 antibody; hFz8 antibody; HGNC4046 antibody; Homolog of Drosophila Frizzled 8 antibody
- Application:
- ELISA, Immunohistochemistry, Western Blot
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Clonality:
- Polyclonal
- Extra Details:
- Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Frizzled-8 protein (55-233AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:FZD8-Antibody-12549441.html
