MAPKAP1 Antibody
Product Sizes
50 ul
£186.00
CSB-PA857767ESR2HU-50UL
100 ul
£334.00
CSB-PA857767ESR2HU-100UL
About this Product
- SKU:
- CSB-PA857767ESR2HU
- Additional Names:
- MAPKAP 1 antibody; MAPKAP1 antibody; MEKK2 interacting protein 1 antibody; MGC2745 antibody; MIP 1 antibody; MIP1 antibody; Mitogen activated protein kinase associated protein 1 antibody; Mitogen-activated protein kinase 2-associated protein 1 antibody; mSIN1 antibody; OTTHUMP00000064207 antibody; Ras inhibitor MGC2745 antibody; SAPK interacting protein 1 antibody; SAPK-interacting protein 1 antibody; SIN 1 antibody; SIN1_HUMAN antibody; SIN1b antibody; SIN1g antibody; Stress activated map kinase interacting protein 1 antibody; Stress activated protein kinase interacting 1 antibody; Stress-activated map kinase-interacting protein 1 antibody; Target of rapamycin complex 2 subunit MAPKAP1 antibody; TORC2 subunit MAPKAP1 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Target of rapamycin complex 2 subunit MAPKAP1 protein (1-290AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:MAPKAP1-Antibody-1091990.html
