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Antibodies

HBEGF Antibody

Product Sizes
50 ug
£186.00
CSB-PA857429LA01HU-50UG
100 ug
£334.00
CSB-PA857429LA01HU-100UG
About this Product
SKU:
CSB-PA857429LA01HU
Additional Names:
diphtheria toxin receptor (heparin-binding EGF-like growth factor) antibody; diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) antibody; Diphtheria toxin receptor antibody; DT R antibody; DT-R antibody; DTR antibody; DTS antibody; DTSF antibody; HB-EGF antibody; HBEGF antibody; HBEGF_HUMAN antibody; HEGFL antibody; Heparin binding EGF like growth factor antibody; Heparin binding epidermal growth factor antibody; Heparin binding epidermal growth factor like growth factor antibody; Heparin-binding EGF-like growth factor antibody; Proheparin binding EGF like growth factor antibody
Application:
ELISA, Immunofluorescence, Immunohistochemistry
Buffer:
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Clonality:
Polyclonal
Extra Details:
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Host:
Rabbit
Immunogen:
Recombinant Human Proheparin-binding EGF-like growth factor protein (63-148AA)
Isotype:
IgG
Physical State:
Liquid
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:
Cusabio
Type:
Antibody: Polyclonal Antibody
Immunofluorescence staining of Hela cells with CSB-PA857429LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of CSB-PA857429LA01HU diluted at 1:100 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA857429LA01HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.