PIWIL1 Antibody
Product Sizes
50 ul
£186.00
CSB-PA846642ESR1HU-50UL
100 ul
£334.00
CSB-PA846642ESR1HU-100UL
About this Product
- SKU:
- CSB-PA846642ESR1HU
- Additional Names:
- HIWI antibody; MIWI antibody; Piwi (Drosophila) like 1 antibody; PIWI antibody; Piwi homolog antibody; Piwi like 1 (drosophila) antibody; Piwi like 1 antibody; Piwi-like protein 1 antibody; PIWIL1 antibody; PIWL1_HUMAN antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator (PubMed:12037681, PubMed:16287078).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Piwi-like protein 1 protein (390-690AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:PIWIL1-Antibody-11909450.html
