Histone H2AX Antibody
Product Sizes
100 ul
£332.00
CSB-PA833019-100UL
About this Product
- SKU:
- CSB-PA833019
- Additional Names:
- H2A histone family member X antibody; H2A histone family member X antibody; H2A.FX antibody; H2A.X antibody; H2a/x antibody; H2AFX antibody; H2AX antibody; H2AX_HUMAN antibody; Histone H2A.X antibody
- Application:
- ELISA, Immunofluorescence, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. The MGC Project Team; Genome Res. 14:2121-2127(2004). Rogakou E.P., J. Biol. Chem. 273:5858-5868(1998). Rogakou E.P., J. Biol. Chem. 275:9390-9395(2000).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human Histone H2AX.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:Histone-H2AX-Antibody-11084867.html
