RFX6 Antibody
Product Sizes
50 ug
£186.00
CSB-PA812809LA01HU-50UG
100 ug
£334.00
CSB-PA812809LA01HU-100UG
About this Product
- SKU:
- CSB-PA812809LA01HU
- Additional Names:
- RFX6 antibody; RFXDC1 antibody; DNA-binding protein RFX6 antibody; Regulatory factor X 6 antibody; Regulatory factor X domain-containing protein 1 antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Clonality:
- Polyclonal
- Extra Details:
- Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).
- Host:
- Rabbit
- Immunogen:
- Recombinant Human DNA-binding protein RFX6 protein (1-260AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:RFX6-Antibody-11110258.html
