MAP2K4 Antibody
Product Sizes
100 ul
£332.00
CSB-PA788410-100UL
About this Product
- SKU:
- CSB-PA788410
- Additional Names:
- c Jun N terminal kinase kinase 1 antibody; C-JUN N-terminal kinase kinase 1 antibody; Dual specificity mitogen activated protein kinase kinase 4 antibody; Dual specificity mitogen-activated protein kinase kinase 4 antibody; JNK Activated Kinase 1 antibody; JNK activating kinase 1 antibody; JNK-activating kinase 1 antibody; JNKK antibody; JNKK1 antibody; MAP kinase kinase 4 antibody; Map2k4 antibody; MAPK ERK kinase 4 antibody; MAPK/ERK kinase 4 antibody; MAPKK 4 antibody; MAPKK4 antibody; MEK 4 antibody; MEK4 antibody; Mitogen activated protein kinase kinase 4 antibody; MKK 4 antibody; MKK4 antibody; MP2K4_HUMAN antibody; PRKMK4 antibody; SAPK ERK kinase 1 antibody; SAPK/ERK kinase 1 antibody; SAPKK 1 antibody; SAPKK1 antibody; SEK1 antibody; SERK1 antibody; SKK1 antibody; Stress activated protein kinase kinase 1 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5). Davis, R.J. (1994) Trends Biochem. Sci. 19, 470-473. Sanchez, I. et al. (1994) Nature 372, 794-798. Yan, M. et al. (1994) Nature 372, 798-800. Kyriakis, J.M. et al. (1994) Nature 369, 156-160. Park, H. et al. (2002) J. Biol. Chem. 277, 2573-2578.
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.352~356(E-S-K-R-P)derived from Human MAP2K4.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:MAP2K4-Antibody-11083264.html
