HNRNPA1 (Ab-192) Antibody
Product Sizes
100 ul
£332.00
CSB-PA737011-100UL
About this Product
- SKU:
- CSB-PA737011
- Additional Names:
- HNRNPA 1 antibody; Helix destabilizing protein antibody; Helix-destabilizing protein antibody; Heterogeneous nuclear ribonucleoprotein A1 antibody; Heterogeneous nuclear ribonucleoprotein A1B protein antibody; Heterogeneous nuclear ribonucleoprotein B2 protein antibody; Heterogeneous nuclear ribonucleoprotein core protein A1 antibody; hnRNP A1 antibody; hnRNP core protein A1 antibody; HNRNPA1 antibody; HNRPA1 antibody; MGC102835 antibody; Nuclear ribonucleoprotein particle A1 protein antibody; ROA1_HUMAN antibody; Single strand DNA binding protein UP1 antibody; Single strand RNA binding protein antibody; Single-strand RNA-binding protein antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts . hnRNP A1 regulates the alternative splicing of c-Src, c-H-Ras and modifies initiation of translation of the fibroblast growth factor 2 mRNA. hnRNP A1 expression level is elevated in many cancers; knockdown of hnRNP A1 leads to apoptosis in various cancer cells . Although predominantly nuclear, hnRNP A1 is continually transported from the nucleus to the cytoplasm where it disassociates from mRNA and is rapidly re-imported into the nucleus . hnRNP A1 binds to cis-acting repressive sequences (CRS) of HIV-1 to influence HIV-1 production . HIV-1 enhances hnRNP A1 expression and promotes the relocalization of hnRNP A1 to the cytoplasm , Myer, V.E. and Steitz, J.A. (1995) RNA 1, 171-82. Rooke, N. et al. (2003) Mol Cell Biol 23, 1874-84. Guil, S. et al. (2003) Mol Cell Biol 23, 2927-41. Bonnal, S. et al. (2005) J Biol Chem 280, 4144-53.
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.190~194(S-S-S-Q-R)derived from Human hnRNP A1.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:HNRNPA1-Ab-192-Antibody-11083267.html
