PGR (Ab-190) Antibody
Product Sizes
100 ul
£332.00
CSB-PA693022-100UL
About this Product
- SKU:
- CSB-PA693022
- Additional Names:
- NR3C3 antibody; Nuclear receptor subfamily 3 group C member 3 antibody; PGR antibody; PR antibody; PRA antibody; PRB antibody; PRGR_HUMAN antibody; Progesterone receptor antibody; Progestin receptor form A antibody; Progestin receptor form B antibody
- Application:
- ELISA, Immunofluorescence, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22. Narayanan R, et al. (2005) Mol Cell Biol; 25(8): 2885-98. Knotts TA, et al. (2001) J Biol Chem; 276(11): 8475-83. Clemm DL, et al. (2000) Mol Endocrinol; 14(1): 52-65. Zhang Y, et al. (1997) Mol Endocrinol; 11(6): 823-32
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.188~192 (G-L-S-P-A) derived from Human Progesterone Receptor.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:PGR-Ab-190-Antibody-11082940.html
