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Antibodies

CALCOCO2 Antibody

Product Sizes
50 ul
£186.00
CSB-PA614394ESR2HU-50UL
100 ul
£334.00
CSB-PA614394ESR2HU-100UL
About this Product
SKU:
CSB-PA614394ESR2HU
Additional Names:
Antigen nuclear dot 52 kDa protein antibody; CACO2_HUMAN antibody; Calcium binding and coiled coil domain 2 antibody; Calcium binding and coiled coil domain containing protein 2 antibody; Calcium-binding and coiled-coil domain-containing protein 2 antibody; CALCOCO 2 antibody; CALCOCO2 antibody; MGC17318 antibody; NDP52 antibody; Nuclear domain 10 protein 52 antibody; Nuclear domain 10 protein antibody; Nuclear domain 10 protein NDP52 antibody; Nuclear domain protein 52 antibody; Nuclear dot protein 52 antibody; OTTHUMP00000218344 antibody; OTTHUMP00000218345 antibody; OTTHUMP00000218346 antibody; OTTHUMP00000218347 antibody; OTTHUMP00000218349 antibody; OTTHUMP00000218351 antibody
Application:
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Buffer:
PBS
Clonality:
Polyclonal
Extra Details:
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).
Host:
Rabbit
Immunogen:
Recombinant Human Calcium-binding and coiled-coil domain-containing protein 2 protein (137-446AA)
Isotype:
IgG
Physical State:
Liquid
Purification:
Affinity Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:
Cusabio
Type:
Antibody: Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA614394ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA614394ESR2HU at dilution of 1:100
Western blot All lanes: CALCOCO2 antibody at 3.66ug/ml Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: 293T whole cell lysate Lane 4: Raji whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 53, 48, 55, 56, 44 kDa Observed band size: 56 kDa
Immunoprecipitating CALCOCO2 in Hela whole cell lysate Lane 1: Rabbit control IgG instead of (1ug) instead of CSB-PA614394ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was uses the Secondary antibody (1/50000) Lane 2: CSB-PA614394ESR2HU (4ug) + Hela whole cell lysate (500ug) Lane 3: Hela whole cell lysate (20ug)