MRE11A Antibody
Product Sizes
100 ul
£332.00
CSB-PA584586-100UL
About this Product
- SKU:
- CSB-PA584586
- Additional Names:
- AT like disease antibody; Ataxia telangiectasia disorder like antibody; ATLD antibody; DNA recombination and repair protein antibody; Double strand break repair protein MRE11A antibody; Double-strand break repair protein MRE11A antibody; endo/exonuclease Mre11 antibody; HNGS1 antibody; meiotic recombination (S. cerevisiae) 11 homolog A antibody; Meiotic recombination 11 homolog 1 antibody; meiotic recombination 11 homolog A (S. cerevisiae) antibody; Meiotic recombination 11 homolog A antibody; MmMRE11A antibody; Mre 11 antibody; MRE 11a antibody; MRE 11b antibody; MRE11 homolog 1 antibody; MRE11 homolog A antibody; MRE11 homolog double strand break repair nuclease antibody; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody; MRE11 meiotic recombination 11 homolog A antibody; MRE11_HUMAN antibody; MRE11A antibody; MRE11b antibody; OTTHUMP00000236830 antibody; OTTHUMP00000236831 antibody; OTTHUMP00000236832 antibody; OTTHUMP00000236833 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Petrini J.H.J., Genomics 29:80-86(1995). Paull T.T., Mol. Cell 1:969-979(1998). Pitts S.A., Hum. Mol. Genet. 10:1155-1162(2001).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human MRE11A.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:MRE11A-Antibody-11085482.html
