KSR2 Antibody
Product Sizes
100 ul
£332.00
CSB-PA581207-100UL
About this Product
- SKU:
- CSB-PA581207
- Additional Names:
- FLJ25965 antibody; hKSR 2 antibody; hKSR2 antibody; Kinase suppressor of Ras 2 antibody; KSR 2 antibody; Ksr2 antibody; KSR2_HUMAN antibody
- Application:
- ELISA, Immunofluorescence, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Ota T., Nat. Genet. 36:40-45(2004). Scherer S.E., Nature 440:346-351(2006). Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human KSR2.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:KSR2-Antibody-11085128.html
