PAK3 (Ab-154) Antibody
Product Sizes
100 ul
£332.00
CSB-PA554964-100UL
About this Product
- SKU:
- CSB-PA554964
- Additional Names:
- PAK3 antibody; OPHN3 antibody; Serine/threonine-protein kinase PAK 3 antibody; EC 2.7.11.1 antibody; Beta-PAK antibody; Oligophrenin-3 antibody; p21-activated kinase 3 antibody; PAK-3 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. Allen K.M., Nat. Genet. 20:25-30(1998). Jiang C., Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. Kitano T., Mol. Biol. Evol. 20:1281-1289(2003).
- Host:
- Rabbit
- Immunogen:
- Synthesized non-phosphopeptide derived from Human PAK3 around the phosphorylation site of serine 154 (Y-M-S(p)-F-T).
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:PAK3-Ab-154-Antibody-11084417.html
