ERN2 Antibody
Product Sizes
50 ul
£186.00
CSB-PA436972-50UL
100 ul
£334.00
CSB-PA436972-100UL
About this Product
- SKU:
- CSB-PA436972
- Additional Names:
- ERN2 antibody; IRE2Serine/threonine-protein kinase/endoribonuclease IRE2 antibody; Endoplasmic reticulum-to-nucleus signaling 2 antibody; Inositol-requiring protein 2 antibody; hIRE2p antibody; Ire1-beta antibody; IRE1b) [Includes: Serine/threonine-protein kinase antibody; EC 2.7.11.1); Endoribonuclease antibody; EC 3.1.26.-)] antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1A Alpha and IRE1B Beta are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of Human ERN2
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ERN2-Antibody-11104677.html
