Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

TRABD2B Antibody

Product Sizes
50 ul
£186.00
CSB-PA406235LA01HU-50UL
100 ul
£334.00
CSB-PA406235LA01HU-100UL
Academic Pricing
Please contact us for academic pricing.
Contact us
About this Product
SKU:
CSB-PA406235LA01HU
Additional Names:
TRABD2B antibody; HKAT antibody; TIKI2 antibody; Metalloprotease TIKI2 antibody; EC 3.4.-.- antibody; Heart antibody; kidney and adipose-enriched transmembrane protein homolog antibody; TRAB domain-containing protein 2B antibody
Application:
ELISA, Immunofluorescence, Immunohistochemistry
Buffer:
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Clonality:
Polyclonal
Extra Details:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Gene Details:
TRABD2B
Host:
Rabbit
Immunogen:
Recombinant Human Metalloprotease TIKI2 protein (195-405AA)
Isotype:
IgG
Physical State:
Liquid
Protein Details:
A6NFA1
Purification:
Affinity Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles.
Supplier:
Cusabio
Type:
Antibody: Polyclonal Antibody
Preservative:
0.03% ProClin™ 300
Long Description:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Synonyms:
heart, kidney and adipose-enriched transmembrane protein homolog;metalloprotease TIKI2;TIKI2;TRAB domain-containing protein 2B;UPF0632 protein A
Immunofluorescence staining of Hela cells with CSB-PA406235LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of CSB-PA406235LA01HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.