lexA Antibody
Product Sizes
50 ug
£186.00
CSB-PA363985HA01ENV-50UG
100 ug
£334.00
CSB-PA363985HA01ENV-100UG
About this Product
- SKU:
- CSB-PA363985HA01ENV
- Additional Names:
- lexA antibody; exrA antibody; spr antibody; tsl antibody; umuA antibody; b4043 antibody; JW4003LexA repressor antibody; EC 3.4.21.88 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Clonality:
- Polyclonal
- Extra Details:
- Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352).
- Host:
- Rabbit
- Immunogen:
- Recombinant Escherichia coli LexA repressor protein (1-202AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Bacteria
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:lexA-Antibody-12552286.html
