P Antibody, Biotin conjugated
Product Sizes
50 ug
£186.00
CSB-PA324598LD01HDO-50UG
100 ug
£334.00
CSB-PA324598LD01HDO-100UG
About this Product
- SKU:
- CSB-PA324598LD01HDO
- Additional Names:
- PProtein P [Includes: DNA-directed DNA polymerase antibody; EC 2.7.7.7); RNA-directed DNA polymerase antibody; EC 2.7.7.49); Ribonuclease H antibody; EC 3.1.26.4)] antibody
- Application:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- Biotin
- Extra Details:
- Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein. Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA). The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
- Host:
- Rabbit
- Immunogen:
- Recombinant Hepatitis B virus genotype A2 subtype adw2 Protein P protein (349-692AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Virus
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:P-AntibodyBiotin-conjugated-11113032.html
