LMP2 Antibody, Biotin conjugated
Product Sizes
50 ug
£186.00
CSB-PA321086HD01EFA-50UG
100 ug
£334.00
CSB-PA321086HD01EFA-100UG
About this Product
- SKU:
- CSB-PA321086HD01EFA
- Additional Names:
- LMP2 antibody; Latent membrane protein 2 antibody; Terminal protein antibody
- Application:
- ELISA
- Buffer:
- Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Clonality:
- Polyclonal
- Conjugate:
- Biotin
- Extra Details:
- Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.
- Host:
- Rabbit
- Immunogen:
- Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Protein G Purified
- Reactivities:
- Virus
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:LMP2-AntibodyBiotin-conjugated-12554129.html
