PDK1 Antibody
Product Sizes
100 ul
£332.00
CSB-PA296362-100UL
About this Product
- SKU:
- CSB-PA296362
- Additional Names:
- [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial antibody; HGNC:8809 antibody; Mitochondrial pyruvate dehydrogenase kinase isoenzyme 1 antibody; PDH kinase 1 antibody; Pdk1 antibody; PDK1_HUMAN antibody; Pyruvate dehydrogenase kinase isoform 1 antibody; Pyruvate dehydrogenase kinase, isoenzyme 1 antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Gudi R., J. Biol. Chem. 270:28989-28994(1995). Ota T., Nat. Genet. 36:40-45(2004). Burkard T.R., BMC Syst. Biol. 5:17-17(2011).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from Internal of Human PDK1.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:PDK1-Antibody-11086156.html
