ACER2 Antibody
Product Sizes
100 ul
£332.00
CSB-PA293630-100UL
About this Product
- SKU:
- CSB-PA293630
- Additional Names:
- ACER2 antibody; ASAH3L antibody; PP11646 antibody; Alkaline ceramidase 2 antibody; AlkCDase 2 antibody; Alkaline CDase 2 antibody; haCER2 antibody; EC 3.5.1.- antibody; EC 3.5.1.23 antibody; Acylsphingosine deacylase 3-like antibody; N-acylsphingosine amidohydrolase 3-like antibody
- Application:
- ELISA, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. Xu R., FASEB J. 20:1813-1825(2006) [PubMed: 16940153]. Wan D.,Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874]. Humphray S.J., Nature 429:369-374(2004) [PubMed: 15164053].
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human ASAH3L.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ACER2-Antibody-11085600.html
