BRCA1 Antibody
Product Sizes
50 ul
£186.00
CSB-PA291937-50UL
100 ul
£334.00
CSB-PA291937-100UL
About this Product
- SKU:
- CSB-PA291937
- Additional Names:
- BRCA 1 antibody; BRCA1 antibody; BRCA1 DNA repair associated antibody; BRCA1/BRCA2 containing complex subunit 1 antibody; BRCA1/BRCA2-containing complex; subunit 1 antibody; BRCA1_HUMAN antibody; BRCAI antibody; BRCC 1 antibody; BRCC1 antibody; Breast and ovarian cancer susceptibility protein 1 antibody; Breast Cancer 1 antibody; Breast Cancer 1 Early Onset antibody; Breast cancer type 1 susceptibility protein antibody; BROVCA1 antibody; FANCS antibody; IRIS antibody; PNCA4 antibody; PPP1R53 antibody; Protein phosphatase 1 regulatory subunit 53 antibody; PSCP antibody; RING finger protein 53 antibody; RNF53 antibody
- Application:
- ELISA, Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of Human BRCA1
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:BRCA1-Antibody-11099177.html
