MADD Antibody
Product Sizes
100 ul
£332.00
CSB-PA265032-100UL
About this Product
- SKU:
- CSB-PA265032
- Additional Names:
- Differentially expressed in normal and neoplastic cells antibody; FLJ35600 antibody; IG20 antibody; Insulinoma glucagonoma clone 20 antibody; KIAA0358 antibody; MADD antibody; MADD_HUMAN antibody; MAP kinase-activating death domain protein antibody; Rab3 GDP/GTP exchange factor antibody; RAB3GEP antibody
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- phosphate buffered saline (without mg2+ and ca2+)
- Clonality:
- Polyclonal
- Extra Details:
- Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. Chow V.T.K., DNA Seq. 6:263-273(1996). Schievella A.R., J. Biol. Chem. 272:12069-12075(1997). Chow V.T.K., Genome 41:543-552(1998).
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from internal of Human MADD.
- Isotype:
- IgG
- Physical State:
- Liquid
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Cusabio
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:MADD-Antibody-11085185.html
